If spots appear on your macbook pro screen spots after using it for a time, first check if it's because of dirt on the surface or a problem with the screen itself. Start by wiping the screen with a soft cloth that is slightly wet with water or a special screen cleaner. This will help remove dust, oil, or other stuff that might look like spots. Next, restart your MacBook. Check the display settings. Look at the brightness and color settings to make sure they are not causing the problem. If the spots are still there, they might be caused by the screen getting hot, pressure on the screen the screen wearing out. Try turning down the brightness and letting the MacBook cool down when you use it for a time. This can help prevent damage to the screen. However, if the spots keep appearing or are still visible on backgrounds it might be a problem, with the screen itself. In that case, it's best to get a professional to take a look or replace the screen. They can help figure out the solution.